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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 1998-362x
Vol. 15, No. 1, 2009, pp. 28-31
Bioline Code: hg09007
Full paper language: English
Document type: Report
Document available free of charge

Indian Journal of Human Genetics, Vol. 15, No. 1, 2009, pp. 28-31

 en Chromosomal abnormalities associated with mental retardation in female subjects
Dutta, Samikshan; Shaw, Jyoti; Sinha, Swagata & Mukhopadhyay Kanchan

Abstract

Chromosomal abnormalities are thought to be the most common cause of mental retardation (MR). However, apart from a few selected types with typical aneuploidy, like Downs syndrome, Klinefelter syndrome, Turner syndrome, etc., the frequency of detectable chromosomal abnormalities in association with idiopathic MR is very low. In this study, we have investigated chromosomal abnormalities in female MR subjects (n = 150) by high-resolution GTG banding. Of them, 30 cases were diagnosed as Downs syndrome. Among the remaining (n = 120), chromosomal abnormalities/marked polymorphisms were detectable in only three MR cases (0.025).

Keywords
Chromosomal abnormalities, GTG-banding, karyotype, MR

 
© Copyright 2009 Indian Journal of Human Genetics.
Alternative site location: http://www.ijhg.com/

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