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Indian Journal of Human Genetics
Medknow Publications on behalf of Indian Society of Human Genetics
ISSN: 0971-6866
EISSN: 0971-6866
Vol. 17, No. 3, 2011, pp. 126-131
Bioline Code: hg11031
Full paper language: English
Document type: Review Article
Document available free of charge

Indian Journal of Human Genetics, Vol. 17, No. 3, 2011, pp. 126-131

 en Neural tube defects between folate metabolism and genetics
Alfarra, Helmi Y.; Alfarra, Sabreen R. & Sadiq, Mai F.


Neural tube defects (NTDs) are the second most common severely disabling human congenital defects. Worldwide, NTDs incidence is approximately one per 1000 live births and varies between 0.78 and 12 per 1000 births in general populations. NTDs causation involves multiple genes, nutritional and environmental factors. Research in the next stage should include bigger populations and bigger studies that would be suitable to detect significant links and conclusions with relatively minor risk factors; analysis of multiple candidate genes to detect potential gene-gene interactions; detailed analysis of patient samples stratified by phenotype.

Folic acid, MTRR, MTR, MTHFR, NTDs

© Copyright 2011 Indian Journal of Human Genetics.
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