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The Journal of Health, Population and Nutrition
ISSN: 1606-0997
EISSN: 1606-0997
Vol. 23, No. 3, 2005, pp. 236-244
Bioline Code: hn05030
Full paper language: English
Document type: Research Article
Document available free of charge

The Journal of Health, Population and Nutrition, Vol. 23, No. 3, 2005, pp. 236-244

 en Routine Use of Antimicrobials by Pregnant Indian Women Does not Improve Birth Outcome: A Randomized Controlled Trial
Sen, Amitava; Mahalanabis, Dilip; Mukhopadhyay, Sanjib; Chakrabarty, Kamalendu; Singh, Arun K.; Bisai, Samiran; Chakrabarty, Monilal; Halder, Debasis & Islam, Mohammad Aminul


Low birth-weight is a leading health problem in developing countries. In a randomized controlled trial, the effect of antimicrobials in pregnant women on improving birth-weight and duration of gestation was evaluated. Two hundred twenty-four pregnant women in their second trimester were randomized to receive metronidazole (200 mg 3 times daily for 7 days) and cephalexin (500 mg twice daily for 5 days) orally by one group. The mean (±SD) birth-weights were 2,545 g (±374) and 2,584 g (±358, p= 0.51), the low birth-weight rates(<2.5 kg) were 40% and 36% (p=0.28), and the prematurity rates were 8% and 11% (p=0.6) in the treated group and the control group respectively. Due to small sample size, it is cautiously concluded that routine antimicrobials for genital and urinary tract infections of pregnant women do not improve birth-weight or duration of gestation. Rather an unexpected observation was the proportion requiring caesarian section or forceps, which was five-fold higher in the treated group (p= 0.001), and given no plausible explanations, this finding needs confirmation. Stunted mothers(<25th centile or 146.4 cm) had two-fold higher risk for low birth-weight (p=0.04) and assisted delivery (p= 0.1). Low maternal body mass index(<25th centile or 18) had six-fold higher risk for stillbirth or abortion (p= 0.007), and high body mass index(>75th centile or 21.2) had three-fold higher risk for assisted delivery (p=0.003).

Birth-weight; Drug therapy; Infant, Low birth-weight; Intrauterine growth retardation; Pregnancy trimester, Second; Pregnancy outcome; Reproductive tract infections; Urinary tract infections; Pregnancy outcomes; Randomized controlled trials; India

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