search
for
 About Bioline  All Journals  Testimonials  Membership  News


The Journal of Health, Population and Nutrition
icddr,b
ISSN: 1606-0997
EISSN: 1606-0997
Vol. 27, No. 6, 2009, pp. 733-738
Bioline Code: hn09075
Full paper language: English
Document type: Research Article
Document available free of charge

The Journal of Health, Population and Nutrition, Vol. 27, No. 6, 2009, pp. 733-738

 en Familial Aggregation of Vibrio cholerae check for this species in other resources -associated Infection in Matlab, Bangladesh
Rahman, Kazi Mizanur; Duggal, Priya; Harris, Jason B.; Saha, Sajal Kumar; Streatfield, Peter Kim; Ryan, Edward T.; Calderwood, Stephen B.; Qadri, Firdausi; Yunus, Mohammad & LaRocque, Regina C.

Abstract

Vibrio cholerae check for this species in other resources is a major cause of diarrhoeal illness in endemic regions, such as Bangladesh. Understanding the factors that determine an individual’s susceptibility to infection due to V. cholerae may lead to improved prevention and control strategies. Increasing evidence suggests that human genetic factors affect the severity of V. cholerae-associated infection. This study, therefore, sought to characterize the heritable component of susceptibility to infection due to V. cholerae using the Matlab Health and Demographic Surveillance System database of the International Centre for Diarrhoeal Disease Research, Bangladesh. In total, 144 pedigrees that included a cholera patient and 341 pedigrees without a cholera patient were evaluated during 1 January–31 December 1992. The odds of the sibling of a patient being admitted with cholera were 7.67 times the odds of the sibling of an unaffected individual being admitted with cholera [95% confidence interval (CI) 2.40-24.5, p<0.001], after adjustment for gender, age, socioeconomic status, and hygiene practices. Although exposure to environmental reservoirs is essential in the epidemiology of cholera, household-specific factors, such as familial relatedness to an index case, may also be important determinants of risk of cholera. Further analysis of human genetic factors that contribute to susceptibility to cholera may be productive.

Keywords
Case-control studies; Cholera; Familial aggregation; Risk factors; Vibrio cholerae; Bangladesh

 
© Copyright 2009 - International Centre For Diarrhoeal Disease Research, Bangladesh
Alternative site location: http://www.jhpn.net

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2023, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil