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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 9, No. 1, 2009, pp. 40-45
Bioline Code: hs09007
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 9, No. 1, 2009, pp. 40-45

 en The anti-mycobacterial activity of Lantana camara check for this species in other resources a plant traditionally used to treat symptoms of tuberculosis in South-western Uganda
Kirimuhuzya, Claude; Waako, Paul; Joloba, Moses & Odyek, Olwa


Introduction: Tuberculosis continues to be a devastating public health problem. Many communities in Uganda use medicinal plants to treat various infections, including respiratory tract infections. There are claims that some can treat tuberculosis. Verifying some of these claims could lead to discovery of lead compounds for development of a TB drug.
Methods: Chloroform and methanol extracts of L. camara collected from South-western Uganda were screened against three strains of Mycobacterium tuberculosis check for this species in other resources using the agar-well diffusion method. H37Rv, the rifampicin-resistant TMC-331 and a non-resistant wild strain (28-25271). The MIC and MBC were determined using the Agar dilution method on Middle brook 7H11.
Results: The methanol extract showed the highest activity against all the three strains used, with zones of inhibition of 18.0-22.5 mm and MIC values of 20 µg/ml for H37Rv and 15 µg/ml for both TMC-331 and wild stain. The values for rifampicin were 1.0 µg/ml for both H37Rv and wild strain but rifampicin hardly showed any activity on TMC-331. The MBC value for the methanol extract of L. camara was 30µg/ml for the H37Rv, and 20µg/ml for both the TMC-331 and wild strains of M. tuberculosis. The MBC for rifampicin was 2.0µg/ml for both H37Rv and the wild strain.
Conclusion: We conclude that L. camara contains principles active against M. tuberculosis, which merit further research.

Anti-mycobacterial; In vitro activity; Medicinal plant; Lantana camara; Mycobacterium tuberculosis; rifampicin

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