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African Health Sciences
Makerere University Medical School
ISSN: 1680-6905
EISSN: 1680-6905
Vol. 9, No. 3, 2009, pp. 174-178
Bioline Code: hs09039
Full paper language: English
Document type: Research Article
Document available free of charge

African Health Sciences, Vol. 9, No. 3, 2009, pp. 174-178

 en Epstein Barr virus latent membrane protein-1 in Hodgkin's lymphoma in Nigerians
Adelusola, KA; Titiloye, NA; Rotimi, O & Durosinmi, M


Background: The burden of lymphomas on the health care system in Nigeria is enormous. Correct diagnosis and identification of aetiological factor are important steps in reducing this burden.
Methods: Eight cases diagnosed as HL within a period of six years at the Obafemi Awolowo University teaching Hospital, Ile-Ife, Nigeria by haematoxylin and eosin (Hand E) only were immunophenotyped using the indirect immunoperoxidase method. Epstein-Barr virus latent membrane protein-1 (LMP-1), CD15 and CD30 immunohistochemistry was also performed. The clinical characteristics of each patient were documented.
Objectives: To document the frequency of involvement of Epstein-Barr virus in cases of HL seen in a university hospital in Nigeria.
Results: Out of the eight cases diagnosed by H&E as HL immunophenotyping showed only five were HL. The rest were non-Hodgkin's lymphoma (2 diffuse large B-cell and 1 null cell ALCL). All were cases of classical HL with 60% being of the mixed cellularity (MC) subtype. There were 2 males and 3 females with ages ranging from 7 years to 40 years. All presented with cervical lymphadenopathy and three had splenomegaly in addition. 60% of the tumour was EBV positive, all of the MC subtype. Three patients had chemotherapy. Eventually all were lost to follow-up. There was no case of the nodular lymphocyte predominance variant.
Conclusion: Mixed cellularity is the most common subtype and is the only subtype associated with EBV positivity in this study. Epstein-Barr virus probably plays an important role in the aetiology of HL in Nigerians.

Epstein-Barr virus, Hodgkin's lymphoma in Nigerians.

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