Indian Journal of Surgery
Medknow Publications on behalf of Association of Surgeons of India
Vol. 68, No. 6, 2006, pp. 306-309
Bioline Code: is06089
Full paper language: English
Document type: Research Article
Document available free of charge
Indian Journal of Surgery, Vol. 68, No. 6, 2006, pp. 306-309
© Copyright 2006 Indian Journal of Surgery.
Do plasma D-dimer levels correlate with disease stage in colonic carcinoma?|
Subramanian Sitalakshmi, Rameshkumar Karuna, Damodar Prema
Background: Hemostasis is deeply involved in tumour growth, angiogenesis and metastasis. Patients with cancer may harbor many alterations of hemostasis and these are multifaceted. The hemostatic changes have been correlated with bulk of tumour and overall patient survival.
Aim: To assess the role of plasma D-dimer levels in correlating with the stage of the disease in patients with colonic carcinoma.
Setting and Design : This study was a prospective study.
Materials and Methods : Sixty-six cases with biopsy-proven diagnosis of adenocarcinoma colon over a period of two years were included. The baseline coagulation tests like platelet count, prothrombin time, activated partial thromboplastin time and plasma D-dimer levels were measured preoperatively in all cases.
Results: The percentage of cases with increased D-dimer and fibrin degradation products (FDP) values were higher in the advanced disease when compared to limited disease.
Statistical Analysis: Chi square test showed statistically significant difference when the results of D-dimer and FDP were compared across the four stages. When the results were compared between limited and advanced disease by the chi square and the Mann Whitney U test, they were found to be statistically significant. ( P < 0.05)
Conclusion: This study shows that a direct correlation exists between D-dimer levels and disease stage in colorectal cancer and therefore D-dimer may provide useful supplementary information to the disease stage in colonic carcinoma.
Colonic carcinoma, D-dimer, stage