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Indian Journal of Medical Microbiology
Medknow Publications on behalf of Indian Association of Medical Microbiology
ISSN: 0255-0857
EISSN: 0255-0857
Vol. 27, No. 1, 2009, pp. 40-43
Bioline Code: mb09009
Full paper language: English
Document type: Short Communication
Document available free of charge

Indian Journal of Medical Microbiology, Vol. 27, No. 1, 2009, pp. 40-43

 en Investigation of T cell Receptors in the Peripheral Blood of Patients with Active Pulmonary Tuberculosis
Akbulut, H.H.; Deveci, F.; Celik, I.; Ilhan, F. & Turgut, T.

Abstract

T cells have the capability of recognizing target cells through their T cell receptors (TCRs). Thus, the percentages of CD3 +/ gamma-delta (γδ) TCR+ and CD3 +/ alpha-beta (αβ) TCR+ T lymphocytes were investigated in active and inactive pulmonary tuberculosis (PT) patients and in healthy individuals. CD3 + and CD3 +/αβ TCR+ cell percentages were significantly lower in all PT patients than in healthy subjects. Percentages of CD3 +/γδ and CD3+/αβ TCR+ were not statistically different between active and inactive PT patients. It was concluded that αβ TCR+ T cells might have a protective role in tuberculosis infection.

Keywords
Alpha/beta T cell, gamma/delta T cell, tuberculosis

 
© Copyright 2009 Indian Journal of Medical Microbiology.
Alternative site location: http://www.ijmm.org

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