en

Complement-dependent lymphocytotoxicity crossmatch in deceased donor renal transplant: A single institutional experience Deepa, R; Balapriya, P; Venkatesh, K G.; Sabeetha, T; Sasikala, J & Jayalakshmi, G Abstract Complement-dependent lymphocytotoxicity crossmatches (n=217) between 47 deceased donors and 150 potential renal recipients were retrospectively studied. A negative cross match was reported in 48 (22.1%), doubtful positive in 126 (58.1%), weakly positive in 32 (14.7%) and positive in 11 (5.1%). No autoantibodies were detected. Renal transplantation was performed in 35.5% of the potential recipients. There was no incidence of hyperacute rejection. The graft survival rate was 88% at 15 months of follow up. The study concludes that a negative pretransplant lympocytotoxicity crossmatch using the basic National Institute of Health technique eliminates hyperacute rejection, but carries drawbacks, which require modification and supplementation with more sensitive and specific assays. Keywords Complement dependant lymphocytotoxicity, cross match, deceased donor renal transplant

© Copyright 2011 Indian Journal of Medical Microbiology.
Alternative site location: http://www.ijmm.org