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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 3, No. 3, 2000, pp. 175-179
Bioline Code: md00049
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 3, No. 3, 2000, pp. 175-179

 en THE EFFECT OF AQUEOUS LEAF EXTRACT OF OCIMUM GRATISSIUM ON HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN RABBITS
EFFRAIM, K.D., SALAMI, H.A. AND OSEWA, T.S

Abstract

The effect of an aqueous leaf extract of Ocimum gratissimum check for this species in other resources (Linn), on haematological and biochemical indices in rabbits was studied. Increasing doses (0.4, 0.8 and 1.6 gkg-1 body weight) of the extract were administered orally to different groups of rabbits for a period of 4 weeks. Significant (P<0.05) decreases in the level of haemoglobin (Hb), packed cell volume (PCV), red blood cells (RBC) and white blood cells (WBC) were observed. The extract significantly (P<0.05, 0.005 and 0.01) reduced the activities of the liver enzymes, alanine aminotransamine (ALT), aspartate aminotransaminase (ASAT) and alkaline phosphatase (ALP). The decreases were dose dependent. There were clinical signs of loss of appetite and general malaise.

 
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