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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 6, No. 1, 2003, pp. 9-14
Bioline Code: md03002
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 6, No. 1, 2003, pp. 9-14

 en MEMBRANE POTENTIAL CHANGE EFFECTS ON CATIONIC AND NEUTRAL DRUG - INDUCED ERYTHROCYTE SHAPE CHANGE AND CELLULAR UPTAKE OF DRUGS.
NWAFOR A AND COAKLEY W. T

Abstract

The effect of membrane potential change of the human erythrocytes on cationic drugs tetracaine and chlorpromazine and neutral drug benzyl alcohol induced cell shape change and red cell uptake of drug has been quantitated using light microscopy and spectrophotometry respectively. At the drug concentration necessary to cause cell membrane cell shape change membrane potential change from -7.1 mV to 1 6.4mV let to the reversal of the cup-forming property of chlorpromazine and tetracaine to that of a crenetor at both 20°C and 37°C. The effect of altering the membrane potential from -7.lmV to 16.4mV also led to the decrease of cellular uptake of drug with increasing membrane diffusion potential. The membrane potential dependent drug induced cell shape change with also reversible on reversing the membrane potential. The results therefore suggest that the cellular uptake of drug and drug induced cell shape change in human erythrocytes was dependent on change in extracellular chloride concentration

Keywords
Membrane potential, cationic drugs, drug uptake, blood, human.

 
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