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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 6, No. 1, 2003, pp. 27-31
Bioline Code: md03005
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 6, No. 1, 2003, pp. 27-31

 en ENHANCEMENT OF CUTANEOUS WOUND HEALING BY METHANOLIC EXTRACTS OF AGERATUM CONYZOIDES check for this species in other resources IN THE WISTAR RAT.
OLADEJO O.W., IMOSEMI I.O., OSUAGWU F.C., OLUWADARA O. O., AIKU A ADEWOYIN O. EKPO O.E, OYEDELE O.O, & AKANG E.E.U

Abstract

In a bid to test the wound healing effect of a crude methanolic extract of Ageratum conyzoides check for this species in other resources (Linn.), 20 animals were divided into two groups of ten animals each representing control and experimental groups. Each animal had a 2cm x 2cm area of skin on the right dorsolateral flank area marked and excised. The resulting area of skin wound in the experimental group was dressed with crude methanolic extract of Ageratum conyzoides at a five daily interval while the animals in the control group were dressed with normal saline at the same interval. The wound area was measured at the tenth post-operative day for animals in both groups and the percentage wound contraction calculated. Sample of granulation tissues and end scar obtained from these animals and prepared by routine paraffin wax method. Fibroblast and blood vessel counts were determined in both groups. The result showed a significant increase in the percentage wound contraction at day 10 in the experimental group compared with the control (82.3 ± 1.6 % vs 55.0 ± 4.2 %), P < 0.05. The wound of animals in both groups showed excellent granulation tissue formation and minimal signs of wound infection. There was a significant reduction in the mean fibroblast count in the experimental group compared with the control (44.2 ± 5.8/ high power field vs 90.2 ± 17. 4 / high power field),P < 0.05. The exact significance of this cannot however be determined. There was no significance difference in the vessel count. It was concluded that extract of Ageratum conyzoides has a better wound healing enhancing action compared with normal saline treated controls. This effect may be due to the antimicrobial properties of Ageratum conyzoides.

Keywords
Wound healing, Ageratum conyzoides, Effect of.

 
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