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African Journal of Biomedical Research
Ibadan Biomedical Communications Group
ISSN: 1119-5096
Vol. 10, No. 2, 2007, pp. 165-173
Bioline Code: md07022
Full paper language: English
Document type: Research Article
Document available free of charge

African Journal of Biomedical Research, Vol. 10, No. 2, 2007, pp. 165-173

 en Pharmacological evidences for antiamnesic potentials of Phyllanthus amarus check for this species in other resources in mice
Joshi, Hanumanthachar & Parle, Milind

Abstract

Phyllanthus amarus check for this species in other resources (PAs) is commonly known as Bhumi amla and is traditionally used since centuries in ayurveda. The present study was undertaken to investigate the effects of PAs on cognitive functions and brain cholinesterase activity in mice. PAs (50, 100 and 200 mg/kg) produced a dose- dependent improvement in memory scores of young and older mice. PAs also reversed successfully the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Interestingly, brain cholinesterase activity was also reduced. The underlying mechanism of action for the observed nootropic effect may be attributed to pro-cholinergic activity exhibited by PAs in the present study. Therefore, it would be worthwhile to explore the therapeutic potential of PAs in the management of patients with cognitive disorders.

Keywords
Phylantus amarus, mice, antiamnesic, memory

 
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