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REVIEW ARTICLE - C-Fos and Its Consequences in Pain
Asma Hayati Ahmad & Zalina Ismail
Abstract
The discovery that c-fos, a proto-oncogene, has a role in pain, has triggered extensive research on the consequences of c-fos expression. It has been shown that c-fos, through its protein form, FOS, leads to expression of dynorphin gene and subsequently dynorphin protein which is implicated in the development of a pain state. This mini review looks at the properties of c-fos and the consequences of its expression following noxious (painful) stimulation.
Keywords
c-fos, pain, dynorphin
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