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REVIEW ARTICLE - ANTITUMOUR-PROMOTING AND CYTOTOXIC CONSTITUENTS OF ETLINGERA ELATIOR
Habsah M, Ali AM, Lajis NH, Sukari MA, Yap YH4, Kikuzaki H, Nakatani N
Abstract
Phytochemical studies on rhizome of Etlingera elatior have resulted in the isolation of 1,7-bis(4-hydroxyphenyl)-2,4,6-heptatrienone (1), demethoxycurcumin (2), 1,7bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (3), 16-hydroxylabda-8(17),11,13trien-16,15-olide (4), stigmast-4-en-3-one (5), stigmast-4-ene-3,6-dione (6), stigmast4-en-6b-ol-3-one (7), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (8). 1 and 4 were new compounds. Compounds 5 and 7 displayed high antitumour-promoting activity. Ethyl acetate extract showed a very significant cytotoxic activity against CEM-SS and MCF-7 cell lines (4 μg/ml and 6.25 μg/ml respectively). The antitumourpromoting activity was determined by EBV-EA assay and cytotoxic activity was determined by MTT assay.
Keywords
Etlingera elatior, antitumour-promoting, EBV-EA, cytotoxic, CEM-SS, MCF-7
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