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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 12, No. 2, 2005, pp. 56-59
Bioline Code: mj05021
Full paper language: English
Document type: Research Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 12, No. 2, 2005, pp. 56-59

 en CASE REPORT - THE CO-EXISTENCE OF PURE RED CELL APLASIA AND AUTOIMMUNE HAEMOLYTIC ANAEMIA IN A CHILD WITH MALIGNANT LYMPHOMA
Suhair Abbas Ahmed & Rosline Hassan

Abstract

The association between pure red cell aplasia (PRCA) and autoimmune haemolytic anaemia (AIHA) has rarely been reported. PRCA represents an isolated process, characterized by normochromic, normocytic anaemia, reticulocytopenia and erythroid hypoplasia in the bone marrow, and may be attributable to infection with Parvo virus B19. AIHA is a condition in which peripheral red blood cell destruction is induced by the presence of autoantibodies. However, the co-existence of these conditions is very rare, since only few cases of PRCA and AIHA associated with malignant lymphoma (ML) were reported. A case of PRCA and AIHA was detected and described, for the first time in Malaysia, in a 10-year-old child suffering from non-Hodgkin lymphoma from the Department of Haematology, Universiti Sains Malaysia. Following the induction course of chemotherapy, the patient turned anaemic, with tendency for red cell clumping, reticulocytopenia and anisocytosis. AIHA was suspected in spite of the weak Coomb reaction obtained. The bone marrow aspirate revealed the presence of giant pronormoblasts, suggesting PRCA. Serological tests for Parvo virus and other viruses were negative.

Keywords
pure red cell aplasia, autoimmune haemolytic anaemia, malignant lymphoma

 
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Alternative site location: http://www.medic.usm.my/publication/mjms/

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