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Alpha Lipoic Acid Prevents Pancreatic Islet Cells Damage and Dyslipidemia in Streptozotocin-Induced Diabetic Rats Budin, Siti Balkis; Kee, Kwa Poi; Eng, Monica Yau Swee; Osman, Khairul; Bakar, Mokhtar Abu & Mohamed, Jamaludin Abstract In the present study, the effects of alpha lipoic acid (ALA) supplementation on glycemic control and lipid profile in streptozotocin (STZ)-induced diabetic rats have been evaluated. Sprague Dawley rats were divided into nondiabetic (NDM), diabetic without supplementation (No Suppl) and diabetic with ALA groups. ALA was orally administered once a day for 8 weeks with a dose of 100 mg/kg BW. Supplementation of ALA to STZ-induced rats prevented the severe damage to the islet cells of the pancreas and lowered the plasma glucose and glycated hemoglobin (HbA1c) levels. Supplementation of ALA also suppressed the increased of total cholesterol (TC), triglycerides and low density lipoprotein-cholesterol (LDL-C) levels in the plasma of diabetic rats as well as increased high density lipoproteincholesterol (HDL-C) levels. In conclusion, this study suggest that ALA may be effective in controlling glycemic status and improving dyslipidemia in streptozotocin-induced diabetic rats and has the potential in reducing cardiovascular complications due to diabetes mellitus. Keywords Alpha lipoic acid; Diabetes mellitus; Islet cells; Hyperglycemia; Dyslipidemia

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