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Malaysian Journal of Medical Sciences
School of Medical Sciences, Universiti Sains Malaysia
ISSN: 1394-195X
Vol. 18, No. 4, 2011, pp. 5-12
Bioline Code: mj11048
Full paper language: English
Document type: Review Article
Document available free of charge

Malaysian Journal of Medical Sciences, Vol. 18, No. 4, 2011, pp. 5-12

 en The Importance of Animal Models in Tuberculosis Vaccine Development
Acosta, Armando; Norazmi, Mohd Nor; Hernandez-Pando, Rogelio; Alvarez, Nadine; Borrero, Reinier; Infante, Juan F & Sarmiento, Maria E


Research, development, and production of vaccines are still highly dependent on the use of animal models in the various evaluation steps. Despite this fact, there are strong interests and ongoing efforts to reduce the use of animals in vaccine development. Tuberculosis vaccine development is one important example of the complexities involved in the use of animal models for the production of new vaccines. This review summarises some of the general aspects related with the use of animals in vaccine research and production, as well as achievements and challenges towards the rational use of animals, particularly in the case of tuberculosis vaccine development.

animal models, animal testing alternatives, research and development, tuberculosis, vaccines

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