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Indian Journal of Medical Sciences
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
ISSN: 0019-5359
EISSN: 1998-3654
Vol. 57, No. 12, 2003, pp. 535-542
Bioline Code: ms03044
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Medical Sciences, Vol. 57, No. 12, 2003, pp. 535-542

 en Absence of Factor V Leiden (G1691A) mutation, FII G20210A allele in coronary artery disease in North India
N Gupta, F Khan, M Tripathi, V P Singh, S Tewari, V Ramesh, N Sinha, S Agrawal

Abstract

Background: Interaction between various genetic and environmental factors is associated with coronary artery diseases (CADs). Factor V Leiden mutation (FVL) and FII G20210A polymorphism are two recently described genetic factors with a propensity towards venous thrombosis, however, with a doubtful role in coronary artery disease and myocardial infarction.
Aim: Present study was conducted to assess the relationship of both these factors in coronary artery disease in population from North India.
Setting and design: Case control study.
Material and methods: Two hundred angiographically proven coronary artery disease patients were studied to examine the association of Factor V Leiden mutation and FII G20210A mutation with coronary artery disease and myocardial infarction. Out of 200 patients, 51 had myocardial infarction. Two hundred controls were selected who were from north India and were also age and sex matched.
Results and conclusions: Our results indicate that both these polymorphisms were totally absent in our population, therefore, these variants cannot be considered as independent risk factors or as a predictor for CAD. However, there is a need to confirm the above findings on patients from different populations from different parts of the country as there are reports which show that the incidence of Factor V Leiden varies from 1.3 % to 10%.

Keywords
Coronary artery disease, Factor V Leiden (G1691A) mutation, Prothrombin gene (F IIG20210A) polymorphism

 
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Alternative site location: http://www.indianjmedsci.org/

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