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Indian Journal of Medical Sciences
Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
ISSN: 0019-5359
EISSN: 0019-5359
Vol. 62, No. 3, 2008, pp. 105-112
Bioline Code: ms08018
Full paper language: English
Document type: Research Article
Document available free of charge

Indian Journal of Medical Sciences, Vol. 62, No. 3, 2008, pp. 105-112

 en Apolipoprotein E polymorphism and its relation to plasma lipids in coronary heart disease
Singh, PP; Singh, M; Bhatnagar, DP; Kaur, TP & Gaur, SK

Abstract

Background : The present investigation is aimed at examining the Apolipoprotein E (APOE) genotypic influence on coronary heart disease (CHD) risk in northwest India (Punjab), where this disease is emerging as a major threat to public-health care system.
Materials and Methods: The present study comprised of angiographically diagnosed coronary heart disease patients (n = 193) and controls (n = 150) of Punjab. Genetic polymorphism of APOE gene was investigated by polymerase chain reaction (PCR), and its association with lipid levels was evaluated.
Results : The allele frequencies of ε2, ε3, and ε4 were 0.054, 0.795, 0.151; and 0.077, 0.856, 0.067 in patients and controls respectively. The bearers of E3/E4 genotype had threefold higher propensity of developing CHD in this population (OR, 3.04; CI, 1.55-6.25; P < 0.001), which exacerbated (OR, 4.18; CI, 2.03-9.27; P < 0.001) after correcting for age, sex, BMI, and lipid-lowering drugs. Lower HDL-C levels and higher LDL-C levels were found to be correlated with E3/E4 genotype (P < 0.01). Other concomitants like body mass index (BMI), total cholesterol (TC), and triglyceride (TG) levels did not show up as genetic determinants in this part of the region.
Conclusions : A significant association (P = 0.016) of ε4 allele, especially E3/E4 genotype, with CHD was observed, along with HDL-C and LDL-C concentrations, in the population of northwest India.

Keywords
APOE, APOE polymorphism, Apolipoprotein E, coronary heart disease, Punjab

 
© Copyright 2008 Indian Journal of Medical Sciences.
Alternative site location: http://www.indianjmedsci.org/

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