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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 50, No. 2, 2002, pp. 174-180
Bioline Code: ni02048
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 50, No. 2, 2002, pp. 174-180

 en Endogenous Sodium-Potassium ATPase Inhibition Related Biochemical Cascade in Trisomy 21 and Huntington's Disease : Neural Regulation of Genomic Function
A. Ravi Kumar, P.A. Kurup


The isoprenoid pathway related cascade was assessed in trisomy 21 and Huntington's disease. Membrane Na+-K+ ATPase activity, serum magnesium and ubiquinone were decreased while HMG CoA reductase activity, serum digoxin and dolichol levels were increased in both the disorders. There were increased levels of tryptophan catabolites (nicotine, strychnine, quinolinic acid and serotonin) and decreased levels of tyrosine catabolites (dopamine, noradrenaline and morphine) in both trisomy 21 and Huntington's disease. There was an increase in dolichol levels, carbohydrate residues of glycoproteins, glycolipids, total/individual GAG fractions and lysosomal enzymes in both disorders. Reduced levels of ubiquinone, reduced glutathione and free radical scavenging enzymes as well as increased lipid peroxidation products and nitric oxide were noticed in both the disorders. The role of hypothalamic digoxin and a disordered isoprenoid pathway in the pathogenesis of trisomy 21 and Huntington's disease is discussed.

Digoxin, Dolichol, Membrane Na+-K+ ATPase, Trinucleotide repeats, Chromosomal non-dysjunction, Magnesium

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