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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 51, No. 1, 2003, pp. 13-15
Bioline Code: ni03001
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 51, No. 1, 2003, pp. 13-15

 en Increased cortical excitability with longer duration of Parkinson's disease as evaluated by transcranial magnetic stimulation
M. Bhatia, S. Johri, M. Behari


Transcranial Magnetic Stimulation (TMS) was used to evaluate the cortical excitability and central motor pathways in Parkinson's disease (PD) and correlate with severity and duration of disease. 19 cases of PD and 13 controls were enrolled. The threshold intensity (TI), cortical latency (CL), central conduction time (CCT), motor evoked potential amplitude (MEP) obtained with TMS were correlated with Hoehn and Yahr and duration of disease. The threshold intensity (TI) was significantly lower in patients of PD than controls. The TI in patients with PD was 53.16±8.4% patients and 67.1±21.6% in controls (p<0.05). This strongly correlated with duration of disease, TI being lower in patients with disease duration more than 5 years. There was no difference in the other TMS parameters CL, CCT, MEP between patients and controls.Our study revealed increased excitability in PD which was related to longer duration of disease.

Parkinson's disease, Cortical excitability, TMS

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