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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 51, No. 4, 2003, pp. 455-460
Bioline Code: ni03150
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 51, No. 4, 2003, pp. 455-460

 en Review Article - Botulinum toxins: Pharmacology and its current therapeutic evidence for use
Muthane U, Panikar D

Abstract

Botulinum toxins are, as a group, among the most potent neuromuscular toxins known, yet they are clinically useful in the management of conditions associated with muscular and glandular over-activity. Botulinum toxins act by preventing release of acetylcholine into the neuromuscular junction. While botulinum toxin type A is commonly available, different manufacturers produce specific products, which are not directly interchangeable and should not be considered as generically equivalent formulations. Type B is also available in the market. Each formulation of botulinum toxin is unique with distinct dosing, efficacy and safety profiles for each use to which it is applied. Botulinum toxin type A is the treatment of choice based on its depth of evidence in dystonias and most other conditions. Botulinum toxin type A is established as useful in the management of spasticity, tremors, headache prophylaxis and several other neurological conditions. Active research is underway to determine the parameters for which the type B toxin can be used in these conditions, as covered in this review. Botulinum toxin use has spread to several fields of medicine.

Keywords
Botulinum toxin, Serotypes, Formulations, Review, Dystonia, Hemifacial spasms, Tremors, Migraine, Tics, Spasticity, Antibody-mediated resistance, Endopeptidase.

 
© Copyright 2003 Neurology India. Online full text also at http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2003;volume=51;issue=4;spage=455;epage=460;aulast=Muthane
Alternative site location: http://www.neurologyindia.com

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