Medknow Publications on behalf of the Neurological Society of India
Vol. 51, No. 4, 2003, pp. 487-489
Bioline Code: ni03157
Full paper language: English
Document type: Research Article
Document available free of charge
Neurology India, Vol. 51, No. 4, 2003, pp. 487-489
© Copyright 2003 Neurology India. Online full text also at http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2003;volume=51;issue=4;spage=487;epage=489;aulast=Reuben
Intravenous immunoglobulin reduces serum tumor necrosis factor α in patients with Guillain-Barre Syndrome|
Reuben S, Sumi MG, Mathai A, Nair MD, Radhakrishnan VV
Background: Tumor necrosis factor a TNF-alpha has a possible role in the pathogenesis of the Guillain-Barre' syndrome (GBS). Aims: To study the effect of intravenous immunoglobulin (IVIg) on serum TNF-alpha concentrations in patients with GBS. Material and Methods: The effect of IVIg on TNF-alpha was evaluated in 36 patients with GBS. Serum TNF-alpha concentration was measured by enzyme-linked immunosorbent assay (ELISA). The sera of 22 (61%) patients with GBS showed elevated concentrations of TNF-alpha (35-182 pg/ml) and these sera were individually incubated in vitro with IVIg (0.25mg/ml) at 37°C for 24 hours. Results: The serum TNF-alpha concentrations in the 22 GBS patients with elevated levels showed a steady decline (60.34-19.78 pg/ml) following incubation with IVIg. These 22 patients also received IVIg therapy, and serum TNF-alpha concentrations showed a significant decline (65.5-9.75 pg/ml) at the end of the therapy. At the time of discharge from the hospital, there was a positive correlation between neurological recovery and decline in TNF-alpha concentrations in these 22 GBS patients. Conclusions: The results of this study indicate that elevated levels of TNF-alpha occur in a proportion of patients with GBS and in these patients elevated serum TNF-alpha levels decline with IVIg therapy.
Guillain-Barre syndrome, Intravenous immunoglobulin, Tumor necrosis factor-alpha.
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