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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 52, No. 4, 2004, pp. 463-465
Bioline Code: ni04156
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 52, No. 4, 2004, pp. 463-465

 en Adult-onset epilepsy and history of childhood febrile seizures: A retrospective study
Mohebbi MohammadR, Navipour Reza, SeyedKazemi Mojdeh, Zamanian Hadi, Khamseh Fatemeh


BACKGROUND: Children with febrile seizures (FS) are at higher risk of developing epilepsy. There is robust literature on epilepsy with onset in childhood following FS but very little on the same issue in adults.
AIMS: We intended to assess the association between adult-onset epilepsy and history of childhood FS.
SETTINGS: The neurology clinic of a university hospital. DESIGN: A retrospective study.
MATERIALS AND METHODS: Records of 101 consecutive adults (≥14 years old) who were referred to our hospital with adult-onset seizures were reviewed and the patients and their families were interviewed to assess the medical history.
STATISTICAL ANALYSIS: Chi-square test and Mantel-Haenszel method.
RESULTS: Of the 101 patients, 9 were excluded for reasons of bacterial meningitis, recent head trauma, brain tumor, tricyclic antidepressants′ overdose and missing reliable data of the childhood FS event. Thirty-one (33.7%) of the remaining 92 patients had history of FS in the childhood (71% men). Localization-related epilepsies were significantly associated with history of FS [Odds ratio: 3.29; (95% CI, 1.30-8.06)] ( χ2= 5.49, df = 1, P=0.012) when compared to other epilepsies and epilepsy syndromes. An initial unprovoked simple partial seizure was also significantly associated with a positive history of FS [Odds ratio: 8.05; (95% CI 2.88-22.45)] ( χ2= 15.86, df = 1, P<0.001).
CONCLUSIONS: Localization-related epilepsies and partial seizures seem to be associated with a history of FS in childhood. This warrants more investigation to understand the mechanism as well as a possible pathology common in both localization-related epilepsies and FS in the affected probands.

Partial epilepsy, seizure, febrile seizure, convulsion, unprovoked, genetic

© Copyright 2004 Neurology India.
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