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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 57, No. 5, 2009, pp. 578-583
Bioline Code: ni09166
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 57, No. 5, 2009, pp. 578-583

 en The correlation between magnetic resonance imaging features of the brainstem and cerebellum and clinical features of spinocerebellar ataxia 3/Machado-Joseph disease
Liang, Xiaochun; Jiang, Hong; Chen, Changqing; Zhou, Gaofeng; Wang, Junling; Zhang, Shen; Lei, Liwang; Wang, Xiaoyi & Tang, Beisha

Abstract

Background : Brainstem and cerebellar atrophy are the most important features in magnetic resonance imaging (MRI) in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD). However, the correlation between brainstem and cerebellar atrophy and the clinical features has not been well studied.
Aim : To study the correlation between MRI features of the brainstem and cerebellum and predominant clinical features in SCA3/MJD.
Design and Setting : University teaching hospital.
Patients and Methods : By using the linear measurement method, we assessed 32 patients with SCA3/MJD to study the correlations between the morphometric data of the brainstem and cerebellum and clinical features: Duration of the disease, age of onset, total international cooperative ataxia rating scale (ICARS) score; total scale for the assessment and rating of ataxia (SARA) score; ICARS subscores, and SARA subscores.
Statistical Analysis : Pearson correlation test.
Results : There was a significant invese correlation between anteroposterior diameter of the midbrain and pons and total ICARS scores, total SARA scores, ICARS and SARA subscores (r= -0.381~-0.57, P < 0.05 or 0.01) and disease duration (r=- 0.42~-0.51, P < 0.05 or 0.01). Additionally, superoinferior diameter of the cerebellum was inversely correlated with total SARA scores and ICARS and SARA subscores except for ataxia of posture and gait in both scales (r=- 0.37~-0.44, P < 0.05). The superoinferior diameter of the fourth ventricle was inversely correlated with age of onset (r=-0.45, P < 0.05).
Conclusion : The effect on the cerebellum and brainstem is related to predominant clinical features in SCA3/MJD patients.

Keywords
Clinical feature, correlation, magnetic resonance imaging, spinocerebellar ataxia type 3/Machado-Joseph disease

 
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