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Parkinson's disease: Functional changes in frontal and parietal cortex using 18 F- fluoro-deoxy glucose positron emission tomography/computed tomography
Hou, Zhongyu; Hong, Shuhui; Sun, Bo; Lin, Xiangtao; Liu, Qingwei; Yao, Shuzhan & Liu, Shuwei
Abstract
Background : In Parkinson′s disease (PD) there is increasing evidence to suggest motor function changes of the cerebral cortex occur in addition to the pathological changes in the extrapyramidal system.
Aims : To explore the functional changes in the frontal and parietal cortex in PD cat model.
Settings and Design : Twenty-four healthy male cats were divided into four animal model groups with the injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), and one control group.
Materials and Methods : Cats in both the animal model and control groups were observed for the behavioral changes. They were also examined by 18 F-fluoro-deoxy glucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT). Region of Interest (ROI) was determined by 18 F-FDG intensity and semi-quantitative analysis was employed after detecting the standard absorption value (SUV).
Statistical Analysis : Statistical significance was evaluated by ANOVA.
Results : Compared to control group, the 18 F-FDG intensity and SUV were found normal on both the sides of frontal and parietal cortex in the PD models on the second day (P > 0.05), and on the fifth day, they were reduced significantly on both the sides of frontal cortex exclusively (P < 0.05). Moreover on the eighth day, the SUV of both frontal cortexes was reduced, while it was increased in both parietal cortex (P < 0.05). Finally on the eleventh day, the SUV remained stable in both the frontal cortex, and was back to normal level in both the parietal cortex.
Conclusions : Functional disorders exist in the frontal cortex of PD animals and aggravate with time. Transient functional enhancement in the parietal cortex of PD cats might be a compensation for the dysfunction of frontal cortex.
Keywords
Cat, frontal and parietal cortex, positron emission tomography/computed tomography, Parkinson′s disease, 18 F-Fluorodeoxyglucose
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