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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 58, No. 1, 2010, pp. 128-130
Bioline Code: ni10029
Full paper language: English
Document type: Case Report
Document available free of charge

Neurology India, Vol. 58, No. 1, 2010, pp. 128-130

 en Dural based primary osteosarcoma in right fronto-temporal region with review of literature
Ghosal, Nandita; Dadlani, Ravi; Furtado, Sunil V.; Bagdi, Naman & Hegde, A. S.


We report a case of primary dural based osteosarcoma in the right fronto-temporal convexity in a 43-year-old female who presented with a short history of seizure and headache. Radiologic evaluation revealed a well defined brightly enhancing extra-axial lesion in the right fronto-temporal region with a dural tail around the sylvian fissure. The overlying bone was uninvolved. Paraffin section of the tumor showed plump cells with moderate nuclear and cellular pleomorphism with eosinophilic extracellular material (osteiod) between the cells. At a few places, lace like osteiod was seen encasing individual cells signifying osteiod being formed by tumor cells. Immunohistochemistry for EMA was focally positive and negative for S-100 protein and GFAP. A final histopathological diagnosis of dural based primary osteosarcoma of the right fronto-temporal region was rendered. To the best of our knowledge this will be the eighth such case in literature.

Central nervous system, dura, extraskeletal osteosarcoma, fronto-temporal

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