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Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 58, No. 3, 2010, pp. 443-445
Bioline Code: ni10112
Full paper language: English
Document type: Report
Document available free of charge

Neurology India, Vol. 58, No. 3, 2010, pp. 443-445

 en Apolipoprotein-E genotypes and myasthenia gravis
Suhail, Hamid; Soundararajan, Christhunesa C.; Vivekanandhan, Subbiah; Singh, Sumit & Behari, Madhuri


Autoimmune myasthenia gravis (MG) is a disorder of neuromuscular junction. Possible role of multiple genes in the development of the MG has been documented. This case-control study, studied the association of apolipoprotein E (Apo-E) alleles with MG. Anti-AChR antibody was measured using radio receptor immunoassay. Apo-E genotypes were analyzed in 120 MG patients and 120 healthy subjects. Comparison between patients with MG and controls showed no significant association with Apo-E allelic variants. However, a significant association of Apo-E4 allele with AChR-antibody positive patients was observed (P = 0.007). Also, among seropositive patients, a significant association was seen between female gender and Apo-E4 allele (P = 0.023). Our results suggest that the presence of Apo-E4 allele might influence seropositive status in patients with MG and seems an associated susceptible factor in female patients.

AChR, Apolipoprotein-E, autoimmunity, myasthenia gravis, genotype

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