About Bioline  All Journals  Testimonials  Membership  News

Neurology India
Medknow Publications on behalf of the Neurological Society of India
ISSN: 0028-3886
EISSN: 0028-3886
Vol. 58, No. 5, 2010, pp. 723-726
Bioline Code: ni10197
Full paper language: English
Document type: Research Article
Document available free of charge

Neurology India, Vol. 58, No. 5, 2010, pp. 723-726

 en Duration of anti-tubercular treatment in tuberculous meningitis: Challenges and opportunity
Prasad, Kameshwar & Sahu, Jitendra Kumar


Background: The duration of anti-tuberculous therapy in tuberculous meningitis is controversial. There is variation in recommendations by different societies and expert groups on this issue.
Objective: To determine the strength of evidence for short-term therapy in tuberculous meningitis through review of literature and critical appraisal.
Materials and Methods: Cochrane CENTRAL (Issue 4, 2010), TRIP database, and PubMed (from 1966 to present) were searched for relevant papers with keywords ′meningeal tuberculosis′ and tuberculous meningitis′ combined with ′chemotherapy′. A critical appraisal of a systematic review was done using standard criteria.
Results: A total of 10 relevant papers were identified. All papers were included in a systematic review. The systematic review did not specify study design of studies to be included, had only case series but no randomised controlled trial, and unclear definition of endpoints.
Conclusions: The evidence base for short-term therapy for tuberculous meningitis is weak. There is a need to conduct a randomised controlled trial with non-inferiority hypothesis of adequate sample size with well-defined end points and adequate follow-up. This is a challenge as well as opportunity for Indian neurologists.

Randomized controlled trial, short-term chemotherapy, systematic review, tuberculous meningitis

© Copyright 2010 Neurology India.
Alternative site location:

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2023, Site last up-dated on 01-Sep-2022.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Google Cloud Platform, GCP, Brazil