Plasmodium falciparum check for this species in other resources - protein synthesis - cell free translation - antimalarial drugs"/>
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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. 2, 2002, pp. 377-380
Bioline Code: oc02072
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 2, 2002, pp. 377-380

 en Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
Ana Ferreras; Ledia Triana; Erlinda Sánchez & Flor Herrera

Abstract

A cell-free system from Plasmodium falciparum check for this species in other resources able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [3H] methionine into parasite proteins even at concentrations higher than the ones found to strongly inhibit the parasite growth. Results clearly indicate that these compounds do not have a direct effect on protein synthesis activity of P. falciparum coded by endogenous mRNA.

Keywords
Plasmodium falciparum check for this species in other resources - protein synthesis - cell free translation - antimalarial drugs

 
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