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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. 4, 2002, pp. 599-600
Bioline Code: oc02114
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 4, 2002, pp. 599-600

 en SHORT COMMUNICATION - Experimental Neuroschistosomiasis - Inadequacy of the Murine Model
Luciana M Silva; Carla Neves de Oliveira & Zilton A Andrade

Abstract

Neuroschistosomiasis is rarely observed in human pathology, but it is of considerable importance. To investigate its pathogenesis, consequences and response to treatment, an experimental model would be desirable, but is not yet available, in spite of a few indications of a suitable mouse model in the literature.

Severe, recent and late Schistosoma mansoni check for this species in other resources infections in outbred and inbred strains of mice revealed widespread distribution of parasite eggs in several organs, but only exceptionally did eggs reach the encephalus, thus revealing the inadequacy of the mouse as an experimental model for neuroschistosomiasis.

Keywords
neuroschistosomiasis - Schistosoma mansoni check for this species in other resources - murine model

 
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