Schistosoma mansoni check for this species in other resources - artemether - transmission electron microscopy - ultrastructural studies - adult worms"/>
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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. 5, 2002, pp. 717-724
Bioline Code: oc02137
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 5, 2002, pp. 717-724

 en Ultrastructural Alterations in Adult Schistosoma mansoni check for this species in other resources Caused by Artemether
Xiao Shuhua; Shen Binggui; Jürg Utzinger; Jacques Chollet & Marcel Tanner

Abstract

Progress has been made over the last decade with the development and clinical use of artemether as an agent against major human schistosome parasites. The tegument has been identified as a key target of artemether, implying detailed studies on ultrastructural damage induced by this compound. We performed a temporal examination, employing a transmission electron microscope to assess the pattern and extent of ultrastructural alterations in adult Schistosoma mansoni check for this species in other resources harboured in mice treated with a single dose of 400 mg/kg artemether. Eight hours post-treatment, damage to the tegument and subtegumental structures was seen. Tegumental alterations reached a peak 3 days after treatment and were characterized by swelling, fusion of distal cytoplasma, focal lysis of the tegumental matrix and vacuolisation. Tubercles and sensory organelles frequently degenerated or collapsed. Typical features of subtegumental alterations, including muscle fibres, syncytium and parenchyma tissues, were focal or extensive lysis, vacuolisation and degeneration of mitochondria. Severe alterations were also observed in gut epithelial cells and vitelline cells of female worms. Our findings of artemether-induced ultrastructural alterations in adult S. mansoni confirm previous results obtained with juvenile S. mansoni and S. japonicum of different ages.

Keywords
schistosomiasis - Schistosoma mansoni check for this species in other resources - artemether - transmission electron microscopy - ultrastructural studies - adult worms

 
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