Schistosoma mansoni check for this species in other resources - Nectomys squamipes check for this species in other resources - C3H/He mice - hepatic granuloma - histopathology - morphometry"/>
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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. s1, 2002, pp. 129-142
Bioline Code: oc02201
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. s1, 2002, pp. 129-142

 en Natural Schistosoma mansoni check for this species in other resources Infection in Nectomys squamipes check for this species in other resources : Histopathological and Morphometric Analysis in Comparison to Experimentally Infected N. squamipes and C3H/He mice
Michele Costa-Silva; Rosângela Rodrigues-Silva; Maarten Hulstijn; Renata Heisler Neves; Mônica de Souza Panasco; Henrique Leonel Lenzi & José Roberto Machado-Silva

Abstract

Histopathologic and morphometric (area, perimeter, major and minor diameters) analysis of hepatic granulomas isolated from twelve naturally infected Nectomys squamipes check for this species in other resources were compared to four experimentally infected ones and six C3H/He mice. Liver paraffin sections were stained for cells and extracellular matrix. Both groups of N. squamipes presented peculiar granulomas consisting predominantly of large macrophages, full of schistosome pigment, characterizing an exudative-macrophage granuloma type, smaller than the equivalent granuloma type in mouse. Naturally infected animals exhibited granulomas in different stages of development, including large number of involutional types. Morphometric analysis showed that all measurements were smaller in naturally infected animals than in other groups. The results demonstrated that both N. squamipes groups reproduced, with small variations, the hepatic granuloma aspects already described in cricetidium ( Calomys callosus check for this species in other resources ), showing a genetic tendency to set up strong macrophage responses and small granulomas. Unexpectedly, natural infection did not engender distinguished histopathological characteristics distinct from those derived from experimental single infection, showing changes predominantly secondary to the duration of infection. It appears that the variability of the inocula (and the number of infections?) interfere more with the quantity than with the quality of the pathological changes, denoting some morpho-functional determinism in the response to schistosomal infection dependent on the animal species.

Keywords
Schistosoma mansoni check for this species in other resources - Nectomys squamipes check for this species in other resources - C3H/He mice - hepatic granuloma - histopathology - morphometry

 
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