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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 98, No. 2, 2003, pp. 209-212
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Bioline Code: oc03056
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 2, 2003, pp. 209-212
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SHORT COMMUNICATION - Anti-human Immunodeficiency Virus-1 Antibody Titers in Injection Drug Users Compared to Sexually Infected Individuals
Vera Bongertz; Elaine Priscilla Ouverney; Sylvia LM Teixeira; Carlos Silva-de-Jesus; Mariana A Hacker; Mariza G Morgado; Francisco I Bastos & The Brazilian Network for HIV Isolation and Characterization
Abstract
Sera from infected injection drug users (IDU) have shown to have antibodies
against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides
more frequently. In this study, reactivity of 48 IDU plasma were compared to
60 plasmas obtained from sexually infected individuals (S). The overall reactivity
of plasma from IDU compared to S was higher, and the reactivity titers were
much higher for IDU plasma than S. IDU plasma also showed a broader antibody
response. The higher reactivity titers were observed mainly for the gp41 immunodominant
epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants
prevalent in Brazil (B, F, C) indicating the specificity in the higher immune
response of IDU.
Keywords
human immunodeficiency virus-1 - antibodies - injection drug users
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