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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 3, 2003, pp. 299-304
Bioline Code: oc03072
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 3, 2003, pp. 299-304

 en SHORT REVIEW - Trypanosoma cruzi check for this species in other resources -elicited CD8+ T Cell-mediated Myocarditis: Chemokine Receptors and Adhesion Molecules as Potential Therapeutic Targets to Control Chronic Inflammation?
Joseli Lannes-Vieira

Abstract

In Chagas disease, during the acute phase, the establishment of inflammatory processes is crucial for Trypanosoma cruzi check for this species in other resources control in target tissues and for the establishment of host/parasite equilibrium. However, in about 30% of the patients, inflammation becomes progressive, resulting in chronic disease, mainly characterized by myocarditis. Although several hypothesis have been raised to explain the pathogenesis of chagasic myocardiopathy, including the persistence of the parasite and/or participation of autoimmune processes, the molecular mechanisms underlying the establishment of the inflammatory process leading to parasitism control but also contributing to the maintenance of T. cruzi-elicited chronic myocarditis remain unsolved. Trying to shed light on these questions, we have for several years been working with murine models for Chagas disease that reproduce the acute self-resolving meningoencephalitis, the encephalitis resulting of reactivation described in immunodeficient individuals, and several aspects of the acute and chronic myocarditis. In the present review, our results are summarized and discussed under the light of the current literature. Furthermore, rational therapeutic intervention strategies based on integrin-mediated adhesion and chemokine receptor-driven recruitment of leukocytes are proposed to control T. cruzi-elicited unbalanced inflammation.

Keywords
Trypanosoma cruzi check for this species in other resources - adhesion molecules - chemokines - inflammation - therapy

 
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