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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 8, 2003, pp. 1083-1087
Bioline Code: oc03211
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 8, 2003, pp. 1083-1087

 en Down-modulation of Lymphoproliferation and Interferon-γ Production by β-glucan Derived from Saccharomyces cerevisiae check for this species in other resources
AC Pelizon; R Kaneno; AMVC Soares; DA Meira & A Sartori

Abstract

β-glucan, one of the major cell wall components of Saccharomyces cerevisiae check for this species in other resources , has been found to enhance immu-ne functions. This study investigated in vivo and in vitro effects of β-glucan on lymphoproliferation and interferon-γ (IFN-γ) production by splenic cells from C57BL/6 female mice. All experiments were performed with particulate b-glucan derived from S. cerevisiae. Data demonstrated that both, i.p administration of particulate b-glucan (20 or 100 μg/animal) and in vitro stimulation of splenic cells (20 or 100 μg/ml of culture) decreased lymphoproliferation and IFN-γ production induced by concanavalin A. These results suggest that β-glucan can trigger a down-modulatory effect regulating a deleterious immune system hyperactivity in the presence of a strong stimulus.

Keywords
Saccharomyces cerevisiae - β-glucan - lymphoproliferation - interferon γ

 
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