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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 4, 2004, pp. 425-431
Bioline Code: oc04075
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 4, 2004, pp. 425-431

 en Oral Candida check for this species in other resources Flora from Brazilian Human Immunodeficiency Virus-infected Patients in the Highly Active Antiretroviral Therapy Era
NR Melo; H Taguchi; J Jorge; RJ Pedro; OP Almeida; K Fukushima; K Nishimura & M Miyaji

Abstract

One of the main opportunistic fungal infections amongst immunocompromised individuals is oral candidosis, which has been found in up to 90% of human immunodeficiency virus (HIV)-infected patients. This study employed yeasts isolated from the saliva and oral cavities of 114 HIV-infected patients living in Campinas, São Paulo. Of the isolates, 57.8% were identified as Candida albicans check for this species in other resources and 42.1% as non-C. albicans. The latter isolates were subsequently identified as C. krusei (7.5%), C. lusitaniae (5.2%), C. tropicalis (4.6%), C. parapsilosis (4.6%), C. glabrata (2.8%), C. kefyr (1.7%), C. guilliermondii (1.7%), C. intermedia (1.1%), C. norvegensis (0.5%), and Rhodotorula rubra check for this species in other resources (1.7%). Susceptibility of the isolates to amphotericin B, fluconazole, miconazole, and itraconazole was also determined by a microdilution method adopted by the National Committee for Clinical Laboratory Standards. The isolates demonstrated various susceptibilities to the antifungal agents. In particular 29 C. albicans and 13 non-C. albicans isolates showed low susceptibility to FLCZ (> 64 μg/ml). This study revealed huge diversity of Candida check for this species in other resources species, in particular the increasing emergence of non-C. albicans associated with the oral flora of HIV-infected patients.

Keywords
Candida - human immunodeficiency virus - antifungal drug - Brazil

 
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