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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 5, 2004, pp. 489-492
Bioline Code: oc04105
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 5, 2004, pp. 489-492

 en Production of L-asparaginase by Filamentous Fungi
Maria Inez de Moura Sarquis; Edna Maria Morais Oliveira; Alberdan Silva Santos & Gisela Lara da Costa


L-asparaginase production was investigated in the filamentous fungi Aspergillus tamarii check for this species in other resources and Aspergillus terreus check for this species in other resources . The fungi were cultivated in medium containing different nitrogen sources. A. terreus showed the highest L-asparaginase (activity) production level (58 U/L) when cultivated in a 2% proline medium. Both fungi presented the lowest level of L-asparaginase production in the presence of glutamine and urea as nitrogen sources. These results suggest that L-asparaginase production by of filamentous fungi is under nitrogen regulation.

filamentous fungi - production of L-asparaginase - Aspergillus tamarii - Aspergillus terreus

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