L-asparaginase production was investigated in the filamentous fungi
Aspergillus tamarii
and
Aspergillus terreus
. The fungi were cultivated in medium containing different nitrogen sources.
A. terreus showed the highest L-asparaginase (activity) production level (58 U/L) when cultivated in a 2% proline medium. Both fungi presented the lowest level of L-asparaginase production in the presence of glutamine and urea as nitrogen sources. These results suggest that L-asparaginase production by of filamentous fungi is under nitrogen regulation.
