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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 1, 2005, pp. 47-49
Bioline Code: oc05009
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 1, 2005, pp. 47-49

 en SHORT COMMUNICATION - Genetic polymorphism of the serine rich antigen N-terminal region in Plasmodium falciparum check for this species in other resources field isolates from Brazil
Evelyn Kety Pratt Riccio; Mariano Gustavo Zalis; Helena Cristina Balthazar Guedes; Dalma Maria Banic; José Maria de Souza; Wilson Alecrim; Daniel Camus; Cláudio Tadeu Daniel-Ribeiro & Maria de Fátima Ferreira-da-Cruz

Abstract

In this work we investigated the frequency of polymorphism in exon II of the gene encoding most of the amino-terminal region of the serine rich antigen (SERA) in Plasmodium falciparum check for this species in other resources field samples. The blood samples were colleted from P. falciparum infected individuals in three areas of the Brazilian Amazon. Two fragments have been characterized by polymerase chain reaction: one of 175 bp corresponding to the repeat region with 5 octamer units and one other of 199 bp related to the 6 repeat octamer units of SERA protein. The 199 bp fragment was the predominant one in all the studied areas. The higher frequency of this fragment has not been described before and could be explained by an immunological selection of the plasmodial population in the infected individuals under study. Since repeat motifs in the amino-terminal region of SERA contain epitopes recognized by parasite-inhibitor antibodies, data reported here suggest that the analysis of the polymorphism of P. falciparum isolates in different geographical areas is a preliminary stage before the final drawing of an universal vaccine against malaria can be reached.

Keywords
malaria - Plasmodium falciparum - serine rich antigen - polymorphism

 
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