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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 3, 2005, pp. 319-324
Bioline Code: oc05091
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 3, 2005, pp. 319-324

 en Slime production and proteinase activity of Candida check for this species in other resources species isolated from blood samples and the comparison of these activities with minimum inhibitory concentration values of antifungal agents
Semiha Ozkan; Fatma Kaynak; Ayse Kalkanci; Ufuk Abbasoglu & Semra Kustimur

Abstract

Slime and proteinase activity of 54 strains consisting of 19 Candida parapsilosis check for this species in other resources and 35 Candida albicans check for this species in other resources strains isolated from blood samples were investigated in this study. Ketoconazole, amphothericin B, and fluconazole susceptibility of Candida check for this species in other resources species were compared with slime production and proteinase activity of these species. For both Candida species, no correlation was detected between the slime activity and minimum inhibitory concentration (MIC) values of the three antifungal agents. For both Candida species no correlation was detected between the proteinase activity and the MIC values of amphothericin B, and fluconazole however, statistically significant difference, was determined between the proteinase activity and MIC values of ketoconazole (p = 0.007). Slime production was determined by using modified Christensen macrotube method and proteinase activity was measured by the method of Staib. Antifungal susceptibility was determined through the guidelines of National Committee for Laboratory Standards (NCCLS M27-A).

Keywords
slime - proteinase activity - Candida spp. - antifungal susceptibility - minimum inhibitory concentration - blood samples

 
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