Slime and proteinase
activity of 54 strains consisting of 19
Candida parapsilosis
and
35
Candida albicans
strains isolated from blood samples were investigated
in this study. Ketoconazole, amphothericin B, and fluconazole susceptibility
of
Candida
species were compared with slime production and proteinase
activity of these species. For both
Candida species, no correlation
was detected between the slime activity and minimum inhibitory concentration
(MIC) values of the three antifungal agents. For both
Candida species
no correlation was detected between the proteinase activity and the MIC
values of amphothericin B, and fluconazole however, statistically significant
difference, was determined between the proteinase activity and MIC values
of ketoconazole (p = 0.007). Slime production was determined by using modified
Christensen macrotube method and proteinase activity was measured by the
method of Staib. Antifungal susceptibility was determined through the guidelines
of National Committee for Laboratory Standards (NCCLS M27-A).
