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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 3, 2005, pp. 325-330
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Bioline Code: oc05092
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 3, 2005, pp. 325-330
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Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans 
Edilson N. Kaneshima & Marialba A. Alves de Castro-Prado
Abstract
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes
previously present in heterozygous. UT448//A757 diploid strain was used
in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were
not observed, 75 and 100 μM benznidazole induced an increasing of
mitotic recombination events in diploid strain. Results were related
to the induction of chromosomal breaks by the antiparasitic drug.
Keywords
benznidazole - somatic recombination - genotoxicity - homozigotization index
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