Complex physalin metabolites present in the capsules of the fruit of
Physalis angulata
L. have been isolated and submitted to a series of assays of antimicrobial activity against
Pseudomonas aeruginosa
ATCC 27853,
Staphylococcus aureus
ATCC 29213, S. aureus ATCC 25923, S. aureus ATCC 6538P,
Neisseria gonorrhoeae
ATCC 49226,
Escherichia coli
ATCC 8739;
E. coli ATCC 25922,
Candida albicans
ATCC 10231 applying different methodologies such as: bioautography, dilution broth, dilution agar, and agar diffusion techniques. A mixture of physalins (pool) containing physalins B, D, F, G inhibit
S. aureus ATCC 29213,
S. aureus ATCC 25923,
S. aureus ATCC 6538P, and
N. gonorrhoeae ATCC 49226 at a concentration of 200 mg/μl, using agar dilution assays. The mixture was inactive against
P. aeruginosa ATCC27853,
E. coli ATCC 8739;
E. coli ATCC 25922,
C. albicans ATCC 10231 when applying bioautography assays. Physalin B (200 μg/ml) by the agar diffusion assay inhibited
S. aureus ATCC 6538P by ± 85%; and may be considered responsible for the antimicrobial activity.
