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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 7, 2005, pp. 779-782
Bioline Code: oc05163
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 7, 2005, pp. 779-782

 en Studies on antimicrobial activity, in vitro, of Physalis angulata check for this species in other resources L. (Solanaceae) fraction and physalin B bringing out the importance of assay determination
Melissa TG Silva; Sonia M Simas; Terezinha GFM Batista; Paola Cardarelli & Therezinha CB Tomassini

Abstract

Complex physalin metabolites present in the capsules of the fruit of Physalis angulata check for this species in other resources L. have been isolated and submitted to a series of assays of antimicrobial activity against Pseudomonas aeruginosa check for this species in other resources ATCC 27853, Staphylococcus aureus check for this species in other resources ATCC 29213, S. aureus ATCC 25923, S. aureus ATCC 6538P, Neisseria gonorrhoeae check for this species in other resources ATCC 49226, Escherichia coli check for this species in other resources ATCC 8739; E. coli ATCC 25922, Candida albicans check for this species in other resources ATCC 10231 applying different methodologies such as: bioautography, dilution broth, dilution agar, and agar diffusion techniques. A mixture of physalins (pool) containing physalins B, D, F, G inhibit S. aureus ATCC 29213, S. aureus ATCC 25923, S. aureus ATCC 6538P, and N. gonorrhoeae ATCC 49226 at a concentration of 200 mg/μl, using agar dilution assays. The mixture was inactive against P. aeruginosa ATCC27853, E. coli ATCC 8739; E. coli ATCC 25922, C. albicans ATCC 10231 when applying bioautography assays. Physalin B (200 μg/ml) by the agar diffusion assay inhibited S. aureus ATCC 6538P by ± 85%; and may be considered responsible for the antimicrobial activity.

Keywords
Physalis angulata L. - antimicrobial methods - physalins

 
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