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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 101, No. 3, 2006, pp. 287-290
Bioline Code: oc06051
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 101, No. 3, 2006, pp. 287-290

 en Antibacterial and cytotoxic activity of Brazilian plant extracts - Clusiaceae
Ivana B Suffredini; Mateus LB Paciencia; Daniela C Nepomuceno; Riad N Younes & Antonio D Varella

Abstract

Twelve extracts obtained from nine plants belonging to six different genera of Clusiaceae were analyzed against Gram-negative ( Escherichia coli check for this species in other resources and Pseudomonas aeruginosa check for this species in other resources ) and Gram-positive ( Staphylococcus aureus check for this species in other resources and Enterococcus faecalis check for this species in other resources ) bacteria using the microdilution broth assay. Tovomita aff. longifolia, T. brasiliensis, Clusia columnaris check for this species in other resources , Garcinia madruno check for this species in other resources , Haploclathra paniculata check for this species in other resources , and Caraipa grandifolia check for this species in other resources extracts showed significant results against the bacteria. The organic extract obtained from the leaves of T. aff. longifolia showed minimal inhibitory concentration (MIC) = 70 μg/ml and minimal bactericidal concentration (MBC) = 90 μg/ml against E. faecalis and the organic extract made with the stem of C. columnaris showed MIC = 180 μg/ml and MBC = 270 μg/ml against P. aeruginosa. None of the antibacterial extracts showed lethal activity against brine shrimp nauplii. On the other hand, both aqueous and organic extracts obtained from the aerial organs of Vismia guianensis check for this species in other resources that were cytotoxic to brine shrimp nauplii did not show a significant antibacterial activity in the assay.

Keywords
antibacterial - cytotoxicity - Clusiaceae - Amazon rain forest - Brazil

 
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