The sensitivity of two Gram positive (
Staphylococcus aureus
Staphylococcus aureus and
Bacillus subtilis
) and two Gram negative (
Escherichia coli
and
Pseudomonas aeruginosa
) pathogenic multi-drug resistant bacteria was tested against the crude extracts (cold aqueous, hot aqueous, and methanol extracts) of leaves and seeds of
Argemone mexicana L. (
Papaveraceae
) by agar well diffusion method. Though all the extracts were found effective, yet the methanol extract showed maximum inhibition against the test microorganisms followed by hot aqueous extract and cold aqueous extract.