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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 101, No. s1, 2006, pp. 365-368
Bioline Code: oc06218
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 101, No. s1, 2006, pp. 365-368

 en Aluminum hydroxide associated to Schistosoma mansoni check for this species in other resources 22.6 kDa protein abrogates partial protection against experimental infection but not alter interleukin-10 production
Lucila GG Pacífico; Cristina T Fonseca; Michele M Barsante; Luciana S Cardoso; Maria Ilma Araújo & Sérgio C Oliveira


The need to develop a vaccine against schistosomiasis led several researches and our group to investigate proteins from Schistosoma mansoni check for this species in other resources as vaccine candidates. Sm22.6 is a protein from S. mansoni that shows high identity with Sj22.6 and Sh22.6 (79 and 91%, respectively). These proteins are associated with high levels of IgE and protection to reinfection. Previously, we have shown that Sm22.6 induced a partial protection of 34.5% when used together with Freund's adjuvant and produced a Th0 type of immune response with interferon-g and interleukin-4. In this work, mice were immunized with Sm22.6 alone or with aluminum hydroxide adjuvant and high levels of IgG, IgG1, and IgG2a were measured. Unfortunately, no protection was detected. Since IL-10 is a modulating cytokine in schistosomiasis, we also observed a high level of this molecule in splenocytes of vaccinated mice. In conclusion, we did not observe the adjuvant effect of aluminum hydroxide associated with rSm22.6 in protective immunity.

Schistosoma mansoni - Sm22.6 - recombinant vaccine - aluminum hydroxide - adjuvant - interleukin-10

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