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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 102, No. 2, 2007, pp. 225-228
Bioline Code: oc07039
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 102, No. 2, 2007, pp. 225-228

 en Treatment of human acute schistosomiasis with oxamniquine induces an increase in interferon-γ response to Schistosoma mansoni check for this species in other resources antigens
de Souza, Joelma R; Morais, Clarice NL; Aroucha, Marcílio L; Miranda, Paulo JC; Barbosa, Constança S; Domingues, Ana Lúcia C; Carvalho Júnior, Luiz B; Abath, Frederico GC & Montenegro, Silvia ML

Abstract

Patients with acute schistosomiasis were studied before and after oxamniquine treatment. They had been exposed to cercariae 5 to 9 weeks before, and presented compatible clinical manifestations, eosinophilia, and high levels of total IgE. Interferon-g (IFN-γ) and interleukin-4 were measured by ELISA in whole blood samples under soluble egg antigen or soluble adult worm preparation stimulation. After treatment, the reduction of leukocytosis and eosinophilia were not significant, but total IgE levels decreased significantly, in contrast to IFN-γ levels that were significantly increased. The oxamniquine treatment of acute schistosomiasis patients is followed by an improvement of a Th1 response in vitro. If this response has a protective aspect is unknown, and some investigations need to be realized.

Keywords
Schistosoma mansoni - acute schistosomiasis - oxamniquine - cytokines

 
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