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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 102, No. 3, 2007, pp. 421-424
Bioline Code: oc07067
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 102, No. 3, 2007, pp. 421-424

 en Merozoite surface protein 2 allelic variation influences the specific antibody response during acute malaria in individuals from a Brazilian endemic area
Sallenave-Sales, Selma; Faria, Clarissa Perez; Zalis, Mariano Gustavo; Daniel-Ribeiro, Cláudio Tadeu & Ferreira-da-Cruz, Maria de Fátima

Abstract

The antibody response to Plasmodium falciparum check for this species in other resources parasites of naturally infected population is critical to elucidate the role of polymorphic alleles in malaria. Thus, we evaluated the impact of antigenic diversity of repetitive and family dimorphic domains of the merozoite surface protein 2 (MSP-2) on immune response of 96 individuals living in Peixoto de Azevedo (MT-Brazil), by ELISA using recombinant MSP-2 proteins. The majority of these individuals were carrying FC27-type infections. IgG antibody responses were predominantly directed to FC27 parasites and were correlated to the extension of polymorphism presented by each MSP-2 region. This finding demonstrated the impact of the genetic polymorphism on antibody response and therefore, its importance on malaria vaccine efficacy.

Keywords
Plasmodium falciparum - merozoite surface protein-2 - antibody response - antigenic polymorphism - malaria

 
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