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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 102, No. 6, 2007, pp. 769-772
Bioline Code: oc07123
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 102, No. 6, 2007, pp. 769-772

 en Immunological and microbiological activity of Davilla elliptica check for this species in other resources St. Hill. (Dilleniaceae) against Mycobacterium tuberculosis check for this species in other resources
Lopes, Flávia Cristine Mascia; Placeres, Marisa Campos Polesi; Jordão Junior, Cleso Mendonça; Higuchi, Célio Takashi; Rinaldo, Daniel; Vilegas, Wagner; Leite, Clarice Queico Fujimura & Carlos, Iracilda Zeppone

Abstract

Mycobacterium tuberculosis check for this species in other resources is responsible for over 8 million cases of tuberculosis (TB) annually. Natural products may play important roles in the chemotherapy of TB. The immunological activity of Davilla elliptica chloroform extract (DECE) was evaluated in vitro by the determination of hydrogen peroxide (H2O2), nitric oxide (NO), and tumor necrosis factor-a (TNF-α) release in peritoneal macrophages cultures. DECE was also tested for its antimycobacterial activity against M. tuberculosis using the microplate alamar blue assay. DECE (50, 150, 250 μg/ml) stimulated the production of H2O2 (from 1,79 ± 0,23 to 7,27 ± 2,54; 15,02 ± 2,86; 20,5 ± 2,1 nmols) (means ± SD), NO (from 2,64 ± 1,02 to 25,59 ± 2,29; 26,68 ± 2,41; 29,45 ± 5,87 μmols) (means ± SD) and TNF-α (from 2,44 ± 1,46 to 30,37 ± 8,13; 38,68 ± 1,59; 41,6 ± 0,90 units/ml) (means ± SD) in a dose-dependent manner and also showed a promising antimycobacterial activity with a minimum inhibitory concentration of 62,5 μg/ml. This plant may have therapeutic potential in the immunological and microbiological control of TB

Keywords
Davilla elliptica - antimycobacterial activity - immunological activity

 
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