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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 103, No. 6, 2008, pp. 545-548
Bioline Code: oc08099
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 103, No. 6, 2008, pp. 545-548

 en Experimental infection parameters in Galea spixii check for this species in other resources (Rodentia: Caviidae) with Leishmania infantum chagasi
Barbosa, Patrícia Batista Barra Medeiros; de Queiroz, Paula Viviane Sousa; Jerônimo, Selma Maria B & Ximenes, Maria de Fátima Freire de Melo

Abstract

In order to better understand the epidemiological transmission network of leishmaniasis, an endemic disease in Northeast Brazil, we investigated the susceptibility of Spix yellow-toothed cavies ( Galea spixii check for this species in other resources ) to the Leishmania infantum chagasi check for this species in other resources parasite. Nine cavies were experimentally infected, separated into three groups and monitored at 30, 90 and 180 days, respectively. Amastigotes were identified in the spleen slides of two cavies killed 180 days after infection. Antibodies against the L. i. chagasi were identified in one of the cavies. This demonstrates that G. spixii is in fact capable of maintaining a stable infection by L. i. chagasi without alterations in biochemical and hematological parameters of the host and without perceivable micro and macroscopic lesions.

Keywords
Galea spixii - Leishmania infantum chagasi - animal hosts

 
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